George Shrinks (born 1990), age 10, is the protagonist of the series. George wakes up from a dream to discover he his small-- "Based on William Joyce's book, George Shrinks is an animated series about a boy who wakes up and discovers he's the size of a mouse"-- from PBS kids website; his golden plated baby shoes were extremely tiny seen in "Round Up The Usual Insects". Because of his small stature, George has had to invent his own adaptive devicees, most notably the Zooper car (a small vehicle which George built with his father, and which can be automatically transformed into an airplane, a helicopter, or a submarine). Another invention is a system of pneumatic tubes, which George also uses for transportation. He is voiced by Tracey Moore.

George has a 2-year-old brother, Junior Shrinks, a mother, Perdita Shrinks, and a father, Harold Shrinks. They are a loving family.